IL-19 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60278-1-Ig |CloneNo.: 8H10H8

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Freight/Packing

Con: 125 μg/150 μl

Choose size:

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Species specificity:
human

Positive WB detected in:
Transfected HEK-293 cells, Recombinant protein

Positive IHC detected in:
human tonsillitis tissue, human breast cancer tissue, human skin cancer tissue, human tonsillitis tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
interleukin 19

Calculated molecular weight:
177aa,20 kDa

Observed molecular weight:
22 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
IL19

Synonyms
IL 10C, IL 19, IL19, interleukin 19, MDA1, NG.1, ZMDA1
Background

IL-19, a member of the IL-10 cytokine family, is expressed in epithelial cells, endothelial cells, and macrophages. It can bind the interleukin-20 receptor complex IL-20R1/IL-20R2 and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). IL-19 induces IL-6 and TNF-alpha production in monocytes. It also induces cell apoptosis and reactive oxygen species production in monocytes, which suggests a role of this cytokine in inflammatory responses. It is up-regulated in monocytes following stimulation with lipopolysaccharide (LPS), and granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-19 alters the balance of Th1 and Th2 cells in favor of Th2 cells. IL-19 contributes to a range of diseases and disorders, such as breast cancer, squamous cell carcinoma of the skin, asthma, endotoxic shock, uremia, psoriasis, rheumatoid arthritis, and periodontal and vascular disease.


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