MEF2C Antibody 16 Publications

Rabbit Polyclonal| Catalog number: 10056-1-AP

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Freight/Packing

Con: 20 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat

Positive WB detected in:
SH-SY5Y cells, mouse colon tissue, SH-SY5Y cells

Positive IP detected in:
SH-SY5Y cells, SH-SY5Y cells

Positive IHC detected in:
human lymphoma tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
myocyte enhancer factor 2C

Calculated molecular weight:
63 kDa

Observed molecular weight:
52 kDa; 63kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MEF2C

Synonyms
MEF2C, myocyte enhancer factor 2C
Background

MEF2C belongs to the MEF2 family. It is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development[PMID: 20221419]. It plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission[PMID:18599438]. It is crucial for normal neuronal development, distribution, and electrical activity in the neocortex and is necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis[PMID: 21666133]. This protein is required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. It may also be involved in neurogenesis and in the development of cortical architecture.

Read more about this antibody on the blog:http://blog.ptglab.com/index.php/mef2c-antibody-features-in-nature-biotechnology/


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