• Featured Product
  • KD/KO Validated

MEF2C Polyclonal antibody

MEF2C Polyclonal Antibody for WB, IP, IF, FC, IHC, ELISA

Host / Isotype

Rabbit / IgG


human, mouse and More (4)





Cat no : 10056-1-AP


MEF2C, myocyte enhancer factor 2C

Tested Applications

Positive WB detected inSH-SY5Y cells, mouse colon tissue, mouse brain tissue, mouse heart tissue
Positive IP detected inSH-SY5Y cells
Positive IHC detected inhuman lymphoma tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHepG2 cells
Positive FC detected inHeLa cells

Recommended dilution

Western Blot (WB)WB : 1:500-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:20-1:200
Immunofluorescence (IF)IF : 1:50-1:500
Flow Cytometry (FC)FC : 0.40 ug per 10^6 cells in a 100 µl suspension
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

10056-1-AP targets MEF2C in WB, IP, IF, FC, IHC, chIP, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse, rat, goat, pig, bovine
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen MEF2C fusion protein Ag0020
Full Name myocyte enhancer factor 2C
Calculated Molecular Weight 51 kDa
Observed Molecular Weight45-70 kDa
GenBank Accession NumberBC156603
Gene Symbol MEF2C
Gene ID (NCBI) 4208
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

MEF2C belongs to the MEF2 family. It is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development[PMID: 20221419]. It plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission[PMID:18599438]. It is crucial for normal neuronal development, distribution, and electrical activity in the neocortex and is necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis[PMID: 21666133]. This protein is required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. It may also be involved in neurogenesis and in the development of cortical architecture. MEF2C exists some isoforms with MV 50-52 kDa, 47 kDa, and 45 kDa, but modified MEF2C is about 55-66 kDa.


Product Specific Protocols
WB protocol for MEF2C antibody 10056-1-APDownload protocol
IHC protocol for MEF2C antibody 10056-1-APDownload protocol
IF protocol for MEF2C antibody 10056-1-APDownload protocol
IP protocol for MEF2C antibody 10056-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Nat Biotechnol

Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.

Authors - Drukker Micha M

Cell Res

Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans.

Authors - Xin-Xin Yu

Nat Neurosci

Stimulus-specific combinatorial functionality of neuronal c-fos enhancers.

Authors - Jae-Yeol Joo

Nat Neurosci

Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.

Authors - Tzyy-Nan Huang

Nat Commun

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism.

Authors - Shichun Tu

Genes Dev

Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone.

Authors - López-Juárez Alejandro A