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Recombinant Mouse IFN-alpha 2/IFNA2 protein (rFc Tag) (HPLC verified)

Species

Mouse

Purity

>90 %, SDS-PAGE
>90 %, SEC-HPLC

Tag

rFc Tag

Activity

not tested

Cat no : Eg3079

Validation Data Gallery

  • Purity of Recombinant Mouse IFN-alpha 2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse IFN-alpha 2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse IFN-alpha 2 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse IFN-alpha 2 was greater than 90% as determined by SEC-HPLC.

Product Information

Purity >90 %, SDS-PAGE
>90 %, SEC-HPLC
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Mouse IFN-alpha 2 protein Cys24-Glu190 (Accession# P01573) with a rabbit IgG Fc tag at the C-terminus.
GeneID 15965
Accession P01573
PredictedSize 45.4 kDa
SDS-PAGE 45-50 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Interferon-alpha (IFN-α) is a type I interferon that plays a crucial role in the immune response. It is produced by various cell types in response to viral infections and other stimuli. IFN-α has multiple functions, including the activation of immune cells, enhancement of antigen presentation, and the induction of antiviral states in cells. In mice, the Ifna2 gene encodes a specific isoform of IFN-α, which is involved in the regulation of the immune system and the defense against pathogens. The expression and function of Ifna2 in mice can be studied using various experimental models, including transgenic and knockout mice. These models help researchers understand the role of IFN-α in immune responses and the development of diseases such as viral infections and autoimmune disorders.

References:

1. Huang C, Jin Y, et al. (2024). Acta Pharm Sin B. 14(11):4914-4933. 
2. Narovlyansky A, et al. (2024). Viruses. 16(11):1718.