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  • KD/KO Validated

NR1H2 Monoclonal antibody

NR1H2 Monoclonal Antibody for FC, WB, ELISA

Host / Isotype

Mouse / IgG1


human, pig and More (1)







Cat no : 60345-1-Ig


Liver X receptor beta, LXR b, LXRB, NER, NER I, NR1H2, Nuclear receptor NER, Oxysterols receptor LXR beta, RIP15, UNR

Tested Applications

Positive WB detected inhuman liver tissue, pig liver tissue
Positive FC detected inHepG2 cells

Recommended dilution

Western Blot (WB)WB : 1:500-1:2000
Flow Cytometry (FC)FC : 0.40 ug per 10^6 cells in a 100 µl suspension
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

60345-1-Ig targets NR1H2 in WB, IHC, FC, ChIP, ELISA applications and shows reactivity with human, pig samples.

Tested Reactivity human, pig
Cited Reactivityhuman, mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen NR1H2 fusion protein Ag5635
Full Name nuclear receptor subfamily 1, group H, member 2
Calculated Molecular Weight 51 kDa
Observed Molecular Weight 51 kDa
GenBank Accession NumberBC047750
Gene Symbol NR1H2
Gene ID (NCBI) 7376
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

NR1H2, also known as LXRB, is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. It preferentially bind to double-stranded oligonucleotide direct repeats, which have the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). It involves in the regulation of cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.


Product Specific Protocols
WB protocol for NR1H2 antibody 60345-1-IgDownload protocol
FC protocol for NR1H2 antibody 60345-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Br J Pharmacol

Functional interplay between LXR and AMPKα inhibits atherosclerosis in apoE deficient mice - A new anti-atherogenic strategy.

Authors - Chuanrui Ma

Front Oncol

EGFR/FOXO3A/LXR-α Axis Promotes Prostate Cancer Proliferation and Metastasis and Dual-Targeting LXR-α/EGFR Shows Synthetic Lethality.

Authors - Tingting Chen

J Lipid Res

25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism.

Authors - Ying Liu
  • KD Validated

J Lipid Res

Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol.

Authors - Ying Liu
  • KO Validated

J Biol Chem

TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells.

Authors - Dan Zhao

J Agric Food Chem

Diosmetin Ameliorates Nonalcoholic Steatohepatitis through Modulating Lipogenesis and Inflammatory Response in a STAT1/CXCL10-Dependent Manner.

Authors - Nanxuan Luo


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


Zehua (Verified Customer) (11-07-2019)

This antibody works well in liver lysates from wild-type and hLXR knockin mouse.

  • Applications: Western Blot,
  • Primary Antibody Dilution: 1:1000
  • Cell Tissue Type: Mouse liver
NR1H2 Antibody Western Blot, validation (1:1000 dilution) in Mouse liver (Cat no:60345-1-Ig)