NR1H2 Monoclonal antibody, PBS Only

• 

  WB analysis of human liver using 60345-1-Ig (same clone as 60345-1-PBS)

  human liver tissue were subjected to SDS PAGE followed by western blot with 60345-1-Ig (NR1H2 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60345-1-PBS in a different storage buffer formulation.

• 

  WB analysis of pig liver using 60345-1-Ig (same clone as 60345-1-PBS)

  pig liver tissue were subjected to SDS PAGE followed by western blot with 60345-1-Ig (NR1H2 Antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60345-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

NR1H2 Monoclonal Antibody for WB, ELISA

Cat No. 60345-1-PBS

Clone No.1E12B10

Host / Isotype

Mouse / IgG1

Reactivity

human, pig

Applications

WB, ELISA

Synonyms

1E12B10, Liver X receptor beta, LXR b, LXRB, NER

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Product Information

60345-1-PBS targets NR1H2 in WB, ELISA applications and shows reactivity with human, pig samples.

• Tested Reactivity: human, pig
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag5635

  Product name: Recombinant human NR1H2 protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 1-461 aa of BC047750

  Sequence: MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE

• Full Name: nuclear receptor subfamily 1, group H, member 2
• Calculated Molecular Weight: 51 kDa
• Observed Molecular Weight: 51 kDa
• GenBank Accession Number: BC047750
• Gene Symbol: NR1H2
• Gene ID (NCBI): 7376
• RRID: AB_2881454
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein G purification
• UNIPROT ID: P55055
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

NR1H2, also known as LXRB, is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. It preferentially bind to double-stranded oligonucleotide direct repeats, which have the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). It involves in the regulation of cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.