NeutraControl IL-23 p19 Monoclonal antibody

NeutraControl IL-23 p19 Monoclonal Antibody for Non-Neutralization, ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human, mouse

Applications

Non-Neutralization, ELISA

Conjugate

Unconjugated

CloneNo.

1A9B9

Cat no : 69506-1-Ig

Synonyms

IL 23, IL 23 A, IL 23 subunit alpha, IL 23A, IL 23p19, IL-23 p19, IL23A, IL23P19, Interleukin 23 subunit alpha, Interleukin 23 subunit p19, P19, SGRF



Product Information

69506-1-Ig targets IL-23 p19 in Non-Neutralization, ELISA applications and shows reactivity with Human, mouse samples.

Tested Reactivity Human, mouse
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen human Humankine IL-23 p19 protein HZ-1254
Full Name interleukin 23, alpha subunit p19
Gene symbol IL23A
Gene ID (NCBI) 51561
RRIDAB_2918849
Conjugate Unconjugated
Form Lyophilized Powder
Purification Method Protein A purification
Storage Buffer Sterile PBS.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Background Information

Interleukin 23 (IL-23) is a member of the IL12 cytokine family and composed of two subunits, IL12p40 and IL23p19. It is produced by antigen presenting cells and has been shown to promote the production and survival of a distinct lineage of T-cells called TH17 cells. A functional receptor for IL-23 (the IL-23 receptor) has been identified and is composed of IL-12Rβ1 and IL-23R. IL-23 is expressed chiefly by the macrophages and DCs. The IL-23R is found on memory T cells, NKT cells, macrophages, DCs, and naive T cells upon activation by TGF-βand IL-6. The main biological effects of IL-23 identified initially are stimulation of antigen presentation by DCs, T cell differentiation to Th17 cells, and production of interferon-γ (IFN-γ). IL-23 acts also as an end-stage effector cytokine through direct action on macrophages (PMID: 16393998;15657292;12023369;12610626).

This antibody is a neutralizing control antibody for IL-23, the immunogen is the same as Neutrakine 69006-1-Ig but could not neutralize human IL-23.