NeutraControl Noggin Monoclonal antibody

NeutraControl Noggin Monoclonal Antibody for Non-Neutralization, ELISA

Host / Isotype

Mouse / IgG2a

Reactivity

Human

Applications

Non-Neutralization, ELISA

Conjugate

Unconjugated

CloneNo.

3B10F3

Cat no : 69510-1-Ig

Synonyms

NOG, noggin, SYM1, SYNS1



Product Information

69510-1-Ig targets Noggin in Non-Neutralization, ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen human Humankine Noggin protein HZ-1118
Full Name noggin
Gene symbol NOG
Gene ID (NCBI) 9241
RRIDAB_2918851
Conjugate Unconjugated
Form Lyophilized Powder
Purification Method Protein A purification
Storage Buffer Sterile PBS.
Endotoxin<0.1 EU/μg
ReconstitutionThis product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use.
Stability and StorageLyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.

Background Information

Noggin is an extracellular polypeptide acting as an antagonist of bone morphogenetic proteins (BMPs) regulating embryonal development. Noggin inhibits activity of BMP-2, -4, -7, -13, and -14. Noggin is present extracellularly in the matrix or retained at the cell surface via interaction with heparin sulfate proteoglycans. In early development stages, Noggin is produced by the Spemann organizer, allowing dorsal-ventral patterning of BMPs (PMID: 8752214). Subsequently, Noggin is expressed by the notochord regulating BMP-4 signaling in neurogenesis. Additionally, Noggin is present during development in the dermal papilla, connective tissue of the hair follicle, lens, retina, and periocular mesenchyme, as well as in the mesoderm lineage regulating development of the bone, cartilage, and muscles.

This antibody is a neutralizing control antibody for Noggin, the immunogen is the same as Neutrakine 69010-1-Ig but could not neutralize human Noggin.