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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human Noggin protein

Activity

Typically ≤ 15 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1118

Synonyms

NOG, noggin, SYM1, SYNS1


  • The protein was resolved by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.

    The protein was resolved by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.

  • The activity was determined by the dose dependent inhibition of rh-BMP-4 induced alkaline phosphate production by ATDC5 cells using pNPP as chromogenic substrate.

    The activity was determined by the dose dependent inhibition of rh-BMP-4 induced alkaline phosphate production by ATDC5 cells using pNPP as chromogenic substrate.

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Technical Specifications

GeneID 9241
Species human
Expression HEK293
Activity Typically ≤ 15 ng/mL EC50
Purity >95%
Molecular Mass 65 kDa, homodimer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human, mouse

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

Noggin is an inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. It is essential for cartilage morphogenesis and joint formation. Noggin inhibits chondrocyte differentiation through its interaction with GDF5 and GDF6 (PMID: 29497255; 29167826; 29094227; 28842965).

Synonyms

NOG, noggin, SYM1, SYNS1

Publications

SpeciesTitle
human

J Tissue Eng Regen Med

Transplantation of multi-ciliated airway cells derived from human iPS cells using an artificial tracheal patch into rat trachea.

Authors - Hideaki Okuyama

Cell Stem Cell

Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability.

Authors - Meiyan Wang
mouse

J Biol Chem

Matrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist.

Authors - XuYang
human

Stem Cells

Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition.

Authors - Shuhei Kanagaki
human

Stem Cell Reports

Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells.

Authors - SatoshiKonishi
human

Biomaterials

Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo.

Authors - Satoshi Ikeo