• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human Noggin protein

Activity

1.5-15 ng/mL EC50

Species Reactivity

human,mouse

Purity

>95%

Cat no : HZ-1118

Synonyms

NOG, noggin, SYM1, SYNS1



Technical Specifications

GeneID 9241
Species Human
Expression HEK293
Activity 1.5-15 ng/mL EC50
Purity >95%
Endotoxin<1 EU/μg
Accession NumberQ13253
Molecular Mass 65 kDa, homodimer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human,mouse

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

Noggin is an inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. It is essential for cartilage morphogenesis and joint formation. Noggin inhibits chondrocyte differentiation through its interaction with GDF5 and GDF6 (PMID: 29497255; 29167826; 29094227; 28842965).

Synonyms

NOG, noggin, SYM1, SYNS1

Publications

SpeciesTitle
human

Nat Methods

Long-term expansion of alveolar stem cells derived from human iPS cells in organoids.

Authors - YukiYamamoto
human

Cell Stem Cell

Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.

Authors - Anindita Sarkar
human

Biomaterials

Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo.

Authors - Satoshi Ikeo
human

Curr Biol

Human-specific regulation of neural maturation identified by cross-primate transcriptomics

Authors - Sara B Linker
human

Stem Cell Reports

Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells.

Authors - SatoshiKonishi
human

Stem Cells

Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition.

Authors - Shuhei Kanagaki

Reviews

The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


FH

Lisa (Verified Customer) (08-11-2022)

The cytokine works well, with results comparable with the ones observed using the same product from other companies.

  • Applications: Cell culture
  • Cell Tissue Type: hiPSCs-derived neurons