• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human Noggin protein


1.5-15 ng/mL

Species Reactivity




Cat no : HZ-1118


NOG, noggin, SYM1, SYNS1

Technical Specifications

GeneID 9241
Species Human
Expression HEK293
Activity(Primary) 1.5-15 ng/mL
Purity >95%
Endotoxin<1 EU/μg
Accession NumberQ13253
Molecular Mass 28 kDa reduced, 50 to 95 kDa non-reduced, homodimer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human,mouse

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1xPBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix.


Noggin is an inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. It is essential for cartilage morphogenesis and joint formation. Noggin inhibits chondrocyte differentiation through its interaction with GDF5 and GDF6 (PMID: 29497255; 29167826; 29094227; 28842965).


NOG, noggin, SYM1, SYNS1



Cell Stem Cell

Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability.

Authors - Meiyan Wang

Nat Methods

Long-term expansion of alveolar stem cells derived from human iPS cells in organoids.

Authors - YukiYamamoto

Cell Stem Cell

Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.

Authors - Anindita Sarkar

Nat Commun

Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells

Authors - Yang Sun


Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo.

Authors - Satoshi Ikeo

Curr Biol

Human-specific regulation of neural maturation identified by cross-primate transcriptomics

Authors - Sara B Linker


The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


Lisa (Verified Customer) (08-11-2022)

The cytokine works well, with results comparable with the ones observed using the same product from other companies.

  • Applications: Cell culture
  • Cell Tissue Type: hiPSCs-derived neurons