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- KD/KO Validated
OMA1 Polyclonal antibody
OMA1 Polyclonal Antibody for IHC, WB, ELISA
Host / Isotype
Rabbit / IgG
human and More (1)
WB, IHC, ELISA
Cat no : 17116-1-AP
|Positive WB detected in||HeLa cells, HEK-293T cells, K-562 cells, HepG2 cells, SKOV-3 cells, MDA-MB-231 cells|
|Positive IHC detected in||human liver tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Western Blot (WB)||WB : 1:1000-1:4000|
|Immunohistochemistry (IHC)||IHC : 1:250-1:1000|
|Sample-dependent, check data in validation data gallery|
17116-1-AP targets OMA1 in WB, IHC, ELISA applications and shows reactivity with human samples.
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||OMA1 fusion protein Ag10803|
|Full Name||OMA1 homolog, zinc metallopeptidase (S. cerevisiae)|
|Calculated molecular weight||524 aa, 60 kDa|
|Observed molecular weight||34, 60 kDa|
|GenBank accession number||BC012915|
|Gene ID (NCBI)||115209|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
OMA1 (Overlapping with the m-AAA protease 1 homolog) is also named as MPRP1 (Metalloprotease-related protein 1) and belongs to the peptidase M48 family. It is a zinc metalloprotease that spans the inner mitochondrial membrane with a number of predicted membrane spanning domains and the 60 kDa form of OMA1 rapidly accumulated concomitantly with the cleavage of all OPA1 variants, the 40 kDa form of OMA1 may be the mature form (M-OMA1), and the 35 kDa is a cleaved form (S-OMA1), with the 60 kDa form being the active enzyme (PMID:20334834, 30518622). This antibody is speicific to OMA1.
|Product Specific Protocols|
|WB protocol for OMA1 antibody 17116-1-AP||Download protocol|
|IHC protocol for OMA1 antibody 17116-1-AP||Download protocol|
|Click here to view our Standard Protocols|
A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.
Peroxiredoxin 3 deficiency induces cardiac hypertrophy and dysfunction by impaired mitochondrial quality control.
The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis.
Sci Total Environ
Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice.
Hum Mol Genet
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
The adenosine A2A receptor antagonist protects against retinal mitochondrial injury in association with an altered network of competing endogenous RNAs.