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PANX1 Polyclonal antibody

PANX1 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG


human, mouse and More (1)





Cat no : 12595-1-AP


MRS1, pannexin 1, PANX1, PX1, UNQ2529

Tested Applications

Positive WB detected inJurkat cells, SH-SY5Y cells, K-562 cells, MDA-MB-231 cells, C2C12 cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:6000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

12595-1-AP targets PANX1 in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PANX1 fusion protein Ag3174
Full Name pannexin 1
Calculated Molecular Weight 426 aa, 48 kDa
Observed Molecular Weight 45-50 kDa, 90 kDa
GenBank Accession NumberBC016931
Gene Symbol PANX1
Gene ID (NCBI) 24145
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PANX1, also named as MRS1, belongs to the pannexin family. It plays a role as a Ca2+-leak channel to regulate ER Ca2+ homeostasis. It is a structural component of the gap junctions and the hemichannels. PANX1 induced the formation of intercellular channels with characteristics of gap junctions. PANX1 is 48-kDa protein which contains 4 transmembrane domains and cytoplasmic N and C termini. It is a mediator of find-me signal/nucleotide release from apoptotic cells. Western blot for Panx1 was also seen in two bands at 45~50 kDa and ~90 kDa. The band of ~90 kDa corresponding to the Panx1 dimer size. (PMID: 24590064, PMID: 19009624)


Product Specific Protocols
WB protocol for PANX1 antibody 12595-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols




Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer.

Authors - Qing Wang

Sci Signal

Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids.

Authors - Maki Kuzuya

PLoS Pathog

Defining the proteolytic landscape during enterovirus infection.

Authors - Mohsan Saeed

Int J Mol Sci

Age-Dependent Activation of Pannexin1 Function Contributes to the Development of Epileptogenesis in Autosomal Dominant Sleep-related Hypermotor Epilepsy Model Rats

Authors - Kouji Fukuyama

Front Oncol

Construction of a Novel Ferroptosis-Related Gene Signature for Predicting Survival of Patients With Lung Adenocarcinoma.

Authors - Xiaojie Song

Biochim Biophys Acta Mol Cell Res

TGF-β2 increases cell-cell communication in chondrocytes via p-Smad3 signalling.

Authors - Mengmeng Duan