PCDHB1 Polyclonal antibody

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  IP experiment of mouse skeletal muscle using 31966-1-AP

  IP result of anti-PCDHB1 (IP:31966-1-AP, 4ug; Detection:31966-1-AP 1:500) with mouse skeletal muscle tissue lysate 1040 ug.

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  IP experiment of rat skeletal muscle using 31966-1-AP

  IP result of anti-PCDHB1 (IP:31966-1-AP, 4ug; Detection:31966-1-AP 1:500) with rat skeletal muscle tissue lysate 1800 ug.

PCDHB1 Polyclonal Antibody for IP, ELISA

Cat No. 31966-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IP, ELISA

Synonyms

Protocadherin beta-1, Protocadherin Beta 1 , PCDH-beta-1

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Tested Applications

• Positive IP detected in: mouse skeletal muscle tissue, rat skeletal muscle tissue

Recommended dilution

• Immunoprecipitation (IP): IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

31966-1-AP targets PCDHB1 in IP, ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen: PCDHB1 fusion protein Ag35435
• Full Name: protocadherin beta 1
• Observed Molecular Weight: 80 kDa
• GenBank Accession Number: BC112096
• Gene Symbol: PCDHB1
• Gene ID (NCBI): 29930
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity Purification
• UNIPROT ID: Q9Y5F3
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

PCDHB1 (Protocadherin Beta 1) is a member of the protocadherin beta gene cluster, which belongs to the Cadherin superfamily and is expressed primarily in the nervous system. It encodes a cell adhesion protein containing six extracellular adhesion protein structural domains and a distinct cytoplasmic tail involved in the establishment and function of intercellular junctions. PCDHB1 plays an important role in neurodevelopment, and its aberrant expression has been associated with a variety of neurodevelopmental disorders, for example, PCDHB1 expression is upregulated in the brains of patients with Rett syndrome, which may be related to the neuropathological features of the disease. In addition, members of the PCDHB1 gene cluster are involved in neuronal self-recognition, avoidance, and connection establishment with other neurons.