CD31 Antibody 25 Publications

Rabbit Polyclonal| Catalog number: 11265-1-AP

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Freight/Packing

Con: 59 μg/150 μl

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Species specificity:
human, monkey

Positive WB detected in:
Jurkat cells

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human hepatocirrhosis tissue, human tonsillitis tissue, human renal cell carcinoma tissue, human lung cancer tissue, human endometrial cancer tissue, human gliomas tissue, human hysteromyoma tissue, human liver tissue

Positive IF detected in:
human tonsillitis tissue

Positive FC detected in:
HUVEC cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:400-1:1600
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
platelet/endothelial cell adhesion molecule

Calculated molecular weight:
83 kDa

Observed molecular weight:
130 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
PECAM1

Synonyms
CD31, EndoCAM, FLJ58394, GPIIA, PECA1, PECAM 1, PECAM1, VEC marker
Background

Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein with a molecular mass of approximately 120-140 kDa. It is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. PECAM-1 is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, PECAM-1 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489).


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