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Cyclophilin B Polyclonal antibody
Cyclophilin B Polyclonal Antibody for IF, IHC, WB, ELISA
Host / Isotype
Rabbit / IgG
human, mouse and More (1)
WB, IHC, IF, ELISA
Cat no : 11607-1-AP
Validation Data Gallery
|Positive WB detected in||HeLa cells, U-937 cells, Raji cells, HepG2 cells, mouse liver tissue, NIH/3T3 cells, Jurkat cells, RAW 264.7 cells, rat liver tissue|
|Positive IHC detected in||human lymphoma tissue, human liver cancer tissue, human pancreas cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||HeLa cells|
|Western Blot (WB)||WB : 1:1000-1:6000|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Immunofluorescence (IF)||IF : 1:20-1:200|
|Sample-dependent, check data in validation data gallery|
|KD/KO||See 1 publications below|
|WB||See 11 publications below|
|IHC||See 3 publications below|
|IF||See 2 publications below|
11607-1-AP targets Cyclophilin B in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse, monkey|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Cyclophilin B fusion protein Ag2161|
|Full Name||peptidylprolyl isomerase B (cyclophilin B)|
|Calculated molecular weight||216 aa, 24 kDa|
|Observed molecular weight||19-24 kDa|
|GenBank accession number||BC032138|
|Gene ID (NCBI)||5479|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.|
PPIB, also named as CYPB, SCYLP, PPIase B and CYP-S1, belongs to the cyclophilin-type PPIase family and PPIase B subfamily. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIB is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes. The full-length of PPIB has 216aa (24 kDa), and a 33aa-signal peptide could be removed in the matrue form (about 19 kDa).
|Product Specific Protocols|
|WB protocol for Cyclophilin B antibody 11607-1-AP||Download protocol|
|IHC protocol for Cyclophilin B antibody 11607-1-AP||Download protocol|
|IF protocol for Cyclophilin B antibody 11607-1-AP||Download protocol|
|Click here to view our Standard Protocols|
Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.
Am J Hum Genet
PPIB mutations cause severe osteogenesis imperfecta.
OGG1 aggravates renal ischemia-reperfusion injury by repressing PINK1-mediated mitophagy
Hum Mol Genet
Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes.
HDAC6 Inhibition Alleviates Ischemia- and Cisplatin-Induced Acute Kidney Injury by Promoting Autophagy
CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.