REDD1 Monoclonal antibody

REDD1 Monoclonal Antibody for WB, ELISA

Host / Isotype

Mouse / IgG1


Human and More (1)







Cat no : 67059-1-Ig


DDIT4, Dig2, FLJ20500, REDD 1, REDD1, RP11 442H21.1, RTP801

Tested Applications

Positive WB detected inPC-3 cells, HeLa cells, LNCaP cells, HepG2 cells, A549 cells, K-562 cells

Recommended dilution

Western Blot (WB)WB : 1:1000-1:8000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

67059-1-Ig targets REDD1 in WB, ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Cited Reactivityhuman
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen REDD1 fusion protein Ag0965
Full Name DNA-damage-inducible transcript 4
Calculated Molecular Weight 25 kDa
Observed Molecular Weight 32-35 kDa
GenBank Accession NumberBC007714
Gene Symbol DDIT4
Gene ID (NCBI) 54541
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

REDD1, also named as RTP801 and DDIT4, belongs to the DDIT4 family. REDD1 promotes neuronal cell death. It is a novel transcriptional target of p53 implicated ROS in the p53-dependent DNA damage response. REDD1 controlled cell growth under energy stress, as an essential regulator of TOR activity through the TSC1/2 complex. REDD-1 expression has also been linked to apoptosis, Aβ toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin[PMID: 19996311]. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level[PMID: 21733849]. REDD-1 negatively regulates the mammalian target of Rapamycin, a serine/threonine kinase often referred to as mTOR[PMID: 22951983]. It is crucial in the coupling of extra- and intracellular cues to mTOR regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness[PMID: 22304497]. REDD1 is a new host defense factor, and chemical activation of REDD1 expression represents a potent antiviral intervention strategy[PMID: 21909097]. The calculated molecular weight of REDD1 is 25 kDa. Because of multiple lysines in the proteins, REDD1 offen migrates around 35 kDa on Western blot[PMID: 19221489].


Product Specific Protocols
WB protocol for REDD1 antibody 67059-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols



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