SAMHD1 Antibody 24 Publications

Rabbit Polyclonal| Catalog number: 12586-1-AP

Featured Product KD/KO validated

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Species specificity:
human, mouse, rat, monkey

Positive WB detected in:
HepG2 cells, human brain tissue, human heart tissue, K-562 cells, L02 cells, mouse heart tissue

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human lung cancer tissue, human colon cancer tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
K-562 cells

Recommended dilution:
WB : 1:500-1:5000
IP : 1:200-1:1000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
SAM domain and HD domain 1

Calculated molecular weight:
626aa,72 kDa

Observed molecular weight:
64-72 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SAMHD1

Synonyms
DCIP, HDDC1, Monocyte protein 5, MOP 5, MOP5, SAM domain and HD domain 1, SAMHD1, SBBI88
Background

SAMHD1, highly expressed by monocytes and monocyte-derived dendritic cells and by monocyte-derived macrophages at a lower extent, is reported as an HIV-1 restriction factor that inhibits the early step of the HIV-1 life cycle. Vpx (virus-like particles containing viral protein X) could overcome this block by interacting with SAMHD1, inducing proteasome-dependent degradation of SAMHD1. Mutations in SAMHD1 cause Aicardi-Goutières syndrome, a genetic encephalopathy with a presumed immune pathogenesis. This antibody 12586-1-AP is raised againt N-terminal 314 amino acids of the full length SAMHD1.


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