|Positive IHC detected in||mouse pancreas tissue, human pancreas cancer tissue|
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
|Positive IF detected in||mouse pancreas tissue|
|Immunohistochemistry (IHC)||IHC : 1:50-1:500|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
10954-1-AP targets Secretogranin III in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse samples.
|Tested Reactivity||human, mouse|
|Cited Reactivity||human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Secretogranin III fusion protein Ag1397|
|Full Name||secretogranin III|
|Calculated molecular weight||53 kDa|
|GenBank accession number||BC014539|
|Gene ID (NCBI)||29106|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Secretogranin III (SCG3), a member of the granin protein family, is expressed specifically in neuronal and endocrine cells. SCG3 was synthesized as a 61- or 63-kDa protein and processed to a 48-kDa form which, in turn, was partially cleaved to fragments of 28 and 20 kDa.
Exp Eye Res
Secretogranin III as a novel target for the therapy of choroidal neovascularization.
Exp Eye Res
Function-first ligandomics for ocular vascular research and drug target discovery.
Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC.
Secretory sorting receptors carboxypeptidase E and secretogranin III in amyloid β-associated neural degeneration in Alzheimer's disease.
Secretogranin III is an astrocyte granin that is overexpressed in reactive glia.
The oncoprotein HBXIP up-regulates SCG3 through modulating E2F1 and miR-509-3p in hepatoma cells.