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  • KD/KO Validated

SNX17 Polyclonal antibody

SNX17 Polyclonal Antibody for IF, IHC, IP, WB,ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, IHC, IF,ELISA

Conjugate

Unconjugated

Cat no : 10275-1-AP

Synonyms

KIAA0064, SNX17, sorting nexin 17



Tested Applications

Positive WB detected inHeLa cells, human brain tissue, mouse skin tissue, mouse brain tissue, HepG2 cells, mouse cerebellum tissue, mouse liver tissue
Positive IP detected inHeLa cells
Positive IHC detected inmouse brain tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected inHepG2 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:4000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
Immunohistochemistry (IHC)IHC : 1:50-1:500
Immunofluorescence (IF)IF : 1:20-1:200
Sample-dependent, check data in validation data gallery

Product Information

10275-1-AP targets SNX17 in WB, IP, IHC, IF,ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen SNX17 fusion protein Ag0355
Full Name sorting nexin 17
Calculated molecular weight 53 kDa
Observed molecular weight 50 kDa
GenBank accession numberBC002524
Gene symbol SNX17
Gene ID (NCBI) 9784
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Sorting nexin 17 (SNX17, synonym: KIAA0064) is a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. SNX17 does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin.

Protocols

Product Specific Protocols
WB protocol for SNX17 antibody 10275-1-APDownload protocol
IHC protocol for SNX17 antibody 10275-1-APDownload protocol
IF protocol for SNX17 antibody 10275-1-APDownload protocol
IP protocol for SNX17 antibody 10275-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Biochim Biophys Acta

Adaptor protein sorting nexin 17 interacts with the scavenger receptor FEEL-1/stabilin-1 and modulates its expression on the cell surface.

Authors - Adachi Hideki H
  • KD Validated
humanWB,IF

Cell Rep

Suppression of Membranous LRP5 Recycling, Wnt/β-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P.

Authors - Fuyao Liu
  • KD Validated
human, mouseWB

J Mol Biol

Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability.

Authors - Hui-Yuan Tseng
humanWB, IF

J Immunol

SNX17 Affects T Cell Activation by Regulating TCR and Integrin Recycling.

Authors - Douglas G Osborne
  • KD Validated
ratWB

Pharmacol Res

SNX17 protects the heart from doxorubicin-induced cardiotoxicity by modulating LMOD2 degradation.

Authors - Yanping Zhang
  • KD Validated
humanWB

J Cell Biol

TFEB controls retromer expression in response to nutrient availability.

Authors - Rachel Curnock