|Positive WB detected in||HUVEC cells, HEK-293T cells|
|Western Blot (WB)||WB : 1:1000-1:8000|
|Sample-dependent, check data in validation data gallery|
28212-1-AP targets SREBF2 in WB, IHC, IF, ELISA applications and shows reactivity with Human samples.
|Cited Reactivity||hamster, human, mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||SREBF2 fusion protein Ag28205|
|Full Name||sterol regulatory element binding transcription factor 2|
|Calculated molecular weight||124 kDa|
|Observed molecular weight||120-130 kDa|
|GenBank accession number||BC056158|
|Gene ID (NCBI)||6721|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
SREBF2,also named as BHLHD2, is a 1141 amino acid protein, which contains 1 bHLH domain and belongs to the SREBP family. SREBF2 localizes in the endoplasmic reticulum membrane and is ubiquitously expressed in adult and fetal tissues. SREBF2 as a transcriptional activator is required for lipid homeostasis. SREBF2 expression is dynamically regulated in response to nutritional and hormonal cues. SREBF2 exists two isoform with molecular weight 124 kDa and 73 kDa.
Front Cell Dev Biol
Brahma Related Gene 1 (Brg1) Regulates Cellular Cholesterol Synthesis by Acting as a Co-factor for SREBP2.
Cell Death Dis
LPCAT1 reprogramming cholesterol metabolism promotes the progression of esophageal squamous cell carcinoma.
Lett Appl Microbiol
Xinnaokang improves cecal microbiota and lipid metabolism to target atherosclerosis.
Dig Dis Sci
Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway.
Eur J Pharmacol
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
LncRNA PCA3 promotes antimony-induced lipid metabolic disorder in prostate cancer by targeting MIR-132-3 P/SREBP1 signaling.