Published Applications
| IF | See 1 publications below |
Product Information
27841-1-AP targets TDP-43 in IF, ELISA applications and shows reactivity with Human, Mouse samples.
| Tested Reactivity | Human, Mouse |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag26155 Product name: Recombinant human TDP-43 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 184-414 aa of BC001487 Sequence: QDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM Predict reactive species |
| Full Name | TAR DNA binding protein |
| Calculated Molecular Weight | 43 kDa |
| Observed Molecular Weight | 37-40 kDa |
| GenBank Accession Number | BC001487 |
| Gene Symbol | TDP-43 |
| Gene ID (NCBI) | 23435 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q13148 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
TDP-43 is a DNA and RNA-binding protein which regulates transcription and splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. TDP-43 can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat and stabilize the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. Besides, it may also be involved in microRNA biogenesis, apoptosis and cell division. 27841-1-AP is a rabbit polyclonal antibody recognises the 37-40 kDa protein because of the cleaved fragments and posttranslationally modification.
Publications
| Species | Application | Title |
|---|---|---|
Free Radic Biol Med Edaravone mitigates TDP-43 mislocalization in human amyotrophic lateral sclerosis neurons with potential implication of the SIRT1-XBP1 pathway | ||
bioRxiv Differential Cellular Mechanisms Underlie Language and Executive Decline in Amyotrophic Lateral Sclerosis |
