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  • KD/KO Validated

VDR Monoclonal antibody

VDR Monoclonal Antibody for IF, WB, ELISA

Host / Isotype

Mouse / IgG2a


Human, mouse, rat and More (1)







Cat no : 67192-1-Ig


NR1I1, VDR, Vitamin D3 receptor

Tested Applications

Positive WB detected inMCF-7 cells, HeLa cells, HSC-T6 cells, T-47D cells, NCCIT cells, COLO 320 cells
Positive IF detected inHepG2 cells

Recommended dilution

Western Blot (WB)WB : 1:2000-1:10000
Immunofluorescence (IF)IF : 1:50-1:500
Sample-dependent, check data in validation data gallery

Product Information

67192-1-Ig targets VDR in WB, IF, ChIP, ELISA applications and shows reactivity with Human, mouse, rat samples.

Tested Reactivity Human, mouse, rat
Cited Reactivityhuman, mouse, rat
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen VDR fusion protein Ag28188
Full Name vitamin D (1,25- dihydroxyvitamin D3) receptor
Calculated molecular weight 48 kDa
Observed molecular weight 48-55 kDa
GenBank accession numberBC060832
Gene symbol VDR
Gene ID (NCBI) 7421
Conjugate Unconjugated
Form Liquid
Purification Method Protein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

The vitamin D receptor (VDR), also known as NR1I1 (nuclear receptor subfamily 1, group I, member 1), is a member of the nuclear receptor family of transcription factors. Upon activation by vitamin D, the VDR forms a heterodimer with the retinoid-X receptor and binds to hormone response elements on DNA resulting in expression or trans-repression of specific gene products.It is an intracellular hormone receptor that specifically binds 1,25(OH)2D3 and mediates its effects. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A). A disorder of vitamin D metabolism results in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. The VDR exists two isoform with the MV 48 kDa and 54 kDa.


Product Specific Protocols
WB protocol for VDR antibody 67192-1-IgDownload protocol
IF protocol for VDR antibody 67192-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols



Front Cell Dev Biol

Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature.

Authors - Shanhe Wang


Asperuloside inhibited epithelial-mesenchymal transition in colitis associated cancer via activation of vitamin D receptor.

Authors - Yingyu Lu
  • KD Validated

Front Microbiol

Vitamin D3 Suppresses Human Cytomegalovirus-Induced Vascular Endothelial Apoptosis via Rectification of Paradoxical m6A Modification of Mitochondrial Calcium Uniporter mRNA, Which Is Regulated by METTL3 and YTHDF3.

Authors - Wenbo Zhu
  • KD Validated

Biochim Biophys Acta Mol Cell Res

TSLP-induced collagen type-I synthesis through STAT3 and PRMT1 is sensitive to calcitriol in human lung fibroblasts.

Authors - Ai Jin

Ann Transl Med

EB1089 promotes the expression of vitamin D receptor in the intestinal epithelial cell line HT-29 and reduces lipopolysaccharide-induced inflammatory response.

Authors - Dong Lu

J Diabetes Res

Sirt1 Mediates Vitamin D Deficiency-Driven Gluconeogenesis in the Liver via mTorc2/Akt Signaling.

Authors - Qi Yuan