Validation Data Gallery
Technical Specifications
| GeneID | 3624 |
| Species | Human |
| Expression | HEK293 |
| Activity(Primary) | 0.5-3.5 ng/mL |
| Specific Activity | minimally 4.00 x 102 IU/mg |
| Purity | >95% |
| Endotoxin | <1 EU/μg |
| Accession Number | P08476 |
| Molecular Mass | 13kDa reduced, 22 kDa non-reduced, homodimer, non-glycosylated |
| Formulation | 1x PBS, See Certificate of Analysis for details |
| Species Reactivity | human,mouse |
Stability and Reconstitution
| Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
|---|---|---|---|
| Lyophilized | -20°C to -80°C | Until Expiry Date | |
| Lyophilized | Room Temperature | 2 weeks | |
| Reconstituted as per CofA | -20°C to -80°C | 6 months | |
| Reconstituted as per CofA | 4°C | 1 week | |
| Avoid repeated freeze-thaw cycles. | |||
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1x PBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently Swirl or tap vial to mix |
Background
Activin A, a member of the TGF-β superfamily, was named for its ability to activate FSH secretion from the anterior pituitary gland (PMID 16885530). Three activins have been identified in human tissues: activin A, activin B, and activinAB, of which activin A is the most studied. Activin A has various functions in regulating cell differentiation, proliferation, apoptosis and carcinogenesis (PMID 8200957). Xeno-free Recombinant Human Activin A is expressed from human 293 cells as disulfide linked homodimers with molecular mass of 25 kDa.
Synonyms
Activin A, Activin beta A chain, EDF, FRP, INHBA, Inhibin beta A chain, inhibin, beta A
Publications
| Species | Title |
|---|---|
Nat Commun Selectively targeting the AdipoR2-CaM-CaMKII-NOS3 axis by SCM-198 as a rapid-acting therapy for advanced acute liver failure | |
Cell Res Visualization of aging-associated chromatin alterations with an engineered TALE system. | |
Biomater Res Self-organized insulin-producing β-cells differentiated from human omentum-derived stem cells and their in vivo therapeutic potential | |
EMBO J HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition. | |
Nat Protoc The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells. |
Reviews
The reviews below have been submitted by verified Proteintech customers who received an incentive for providing their feedback.
FH Ryszard (Verified Customer) (03-21-2025) | I was able to use this humankine Activin A to great succes to generate 3D tubular structures derived from iPS cells. The powder is easy to resuspend and seems stable at 4C for almost 2 weeks. I will check for Vascular markers at somepoint but looks very promising.
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FH Enes Yagiz (Verified Customer) (08-23-2022) | It is able differentiate human embryonic stemcells into primitive endoderm
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FH Tobias (Verified Customer) (09-13-2021) | HumanKine Activin A is a great product for stem cells, allowing successful differentiation.
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