• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human BMP-7 protein

Activity

<100 ng/mL EC50

Species Reactivity

human,mouse

Purity

>95%

Cat no : HZ-1229

Synonyms

BMP 7, BMP7, BMP-7, bone morphogenetic protein 7, Eptotermin alfa, HZ1229, OP 1, OP1, Osteogenic protein 1



Technical Specifications

GeneID 655
Species Human
Expression HEK293
Activity <100 ng/mL EC50
Purity >95%
Endotoxin<1 EU/µg
Accession NumberP18075
Molecular Mass 20 kDa, homodimer, glycosylated
Formulation 10mM Acetic Acid
Species Reactivity human,mouse

Stability and Reconstitution

Stability and StorageProduct FormTemperature ConditionsStorage Time
(From Date of Receipt)
Lyophilized-20°C to -80°CUntil Expiry Date
LyophilizedRoom Temperature2 weeks
Reconstituted as per CofA-20°C to -80°C6 months
Reconstituted as per CofA4°C1 week
Avoid repeated freeze-thaw cycles.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in 10mM Acetic Acid containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

Bone morphogenetic protein-7 (BMP7), also known as osteogenic protein-1 or OP-1, plays a key role in the differentiation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis (PMID: 15621726). It is expressed in the brain, kidneys and bladder. BMP7 is also present in several cancers, including breast, prostate, and colon cancers (PMID: 16419056, PMID: 15531927). Overexpression of BMP7 mRNA in colorectal cancer patients is significantly associated with poor prognosis and low overall survival (PMID: 18259822). Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC (PMID: 23179403).

Synonyms

BMP 7, BMP7, BMP-7, bone morphogenetic protein 7, Eptotermin alfa, HZ1229, OP 1, OP1, Osteogenic protein 1

Publications

SpeciesTitle
human

Biochem Biophys Res Commun

Angiopoietin-like 4 enhances metastasis and inhibits apoptosis via inducing bone morphogenetic protein 7 in colorectal cancer cells.

Authors - XuquanLi
human

J Recept Signal Transduct Res

Functional expression of BMP7 receptors in oral epithelial cells. Interleukin-17F production in response to BMP7.

Authors - KensukeNishio
human

Regen Med

A human embryonic stem cell-derived clonal progenitor cell line with chondrogenic potential and markers of craniofacial mesenchyme.

Authors - HalSternberg
human

Regen Med

Seven diverse human embryonic stem cell-derived chondrogenic clonal embryonic progenitor cell lines display site-specific cell fates.

Authors - HalSternberg
human

Biomed Mater

Osteogenic differentiation system based on biopolymer nanoparticles for stem cells in simulated microgravity.

Authors - Xiao-Hong Zhao

Neuroscience

BMP5 expression in the adult rat brain.

Authors - YKusakawa

Reviews

The reviews below have been submitted by verified Proteintech customers who received an incentive forproviding their feedback.


FH

Alessandro (Verified Customer) (07-27-2022)

Reliable supplement for dopaminergic neurons maturation

  • Applications: Cell culture
  • Cell Tissue Type: Dopaminergic Neurons
FH

Raffaele (Verified Customer) (06-06-2022)

Very good product, used at IC50 concentration is efficient, we register both morphological and molecular changes with very low mortality.

  • Applications: Cell culture
  • Cell Tissue Type: mesothelial cells Met5A