- HEK293 expressed
- Animal-component free
Animal-free Recombinant Human BMP-7
Typically ≤ 100 ng/mL EC50
Cat no : HZ-1229
OP-1 BMP 7, BMP7, OP 1, OP7
|Activity||Typically ≤ 100 ng/mL EC50|
|Molecular Mass||29 kDa, homodimer, glycosylated|
|Formulation||10mM Acetic Acid, See Certificate of Analysis for details|
|Species Reactivity||human, mouse|
Stability and Reconstitution
|Stability and Storage||Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.|
|Reconstitution||Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in 10mM Acetic Acid containing 0.1% endotoxin-free recombinant human serum albumin (HSA).|
Animal-free Recombinant Human BMP-7 is expressed in human 293 cells as a disulfide linked homodimeric glycoprotein with an apparent molecular mass of 29 kDa. This cytokine is produced in a serum-free, chemically defined media. Recombinant Human BMP-7 is a homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 315 to 431 of the full-length BMP-7 precursor. The protein encoded by this gene is a member of the TGF-beta superfamily. Like other members of the Bone Morphogenetic Protein family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage.
Bone morphogenetic protein-7 (BMP7), also known as osteogenic protein-1 or OP-1, plays a key role in the differentiation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis (PMID: 15621726). It is expressed in the brain, kidneys and bladder. BMP7 is also present in several cancers, including breast, prostate, and colon cancers (PMID: 16419056, PMID: 15531927). Overexpression of BMP7 mRNA in colorectal cancer patients is significantly associated with poor prognosis and low overall survival (PMID: 18259822). Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC (PMID: 23179403).
OP-1 BMP 7, BMP7, OP 1, OP7
Biochem Biophys Res Commun
Angiopoietin-like 4 enhances metastasis and inhibits apoptosis via inducing bone morphogenetic protein 7 in colorectal cancer cells.
J Recept Signal Transduct Res
Functional expression of BMP7 receptors in oral epithelial cells. Interleukin-17F production in response to BMP7.
A human embryonic stem cell-derived clonal progenitor cell line with chondrogenic potential and markers of craniofacial mesenchyme.
Seven diverse human embryonic stem cell-derived chondrogenic clonal embryonic progenitor cell lines display site-specific cell fates.
BMP5 expression in the adult rat brain.
J Tissue Eng Regen Med
An Easy Long-acting BMP7 Release System Based on Biopolymer Nanoparticles for Inducing Osteogenic Differentiation of Adipose Mesenchymal Stem Cells.