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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human HGF protein

Activity

Typically ≤ 20 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1084

Synonyms

F TCF, Hepatocyte growth factor, Hepatopoeitin A, HGF, HGFB, HPTA, Scatter factor, SF



Technical Specifications

GeneID 3082
Species human
Expression HEK293
Activity Typically ≤ 20 ng/mL EC50
Purity >95%
Molecular Mass 70 kDa, single chain, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity Human, monkey, mouse

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Background

Hepatocyte growth factor (HGF) is the most potent mitogen of mature hepatocytes in primary culture. It is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin (PMID 1530787, 2531289). HGF exerts a variety of effects on several cells, such as inflammation, tissue repair, morphogenesis, angiogenesis, tumour propagation, immunomodulation of viral infections and cardio-metabolic activities (PMID: 1846706; 15070743; 1383237; 1827664).

Synonyms

F TCF, Hepatocyte growth factor, Hepatopoeitin A, HGF, HGFB, HPTA, Scatter factor, SF

Publications

SpeciesTitle
human

Cell Death Discov

Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells.

Authors - Emarndeena H Cheteh
human

Zhongguo Fei Ai Za Zhi

[c-Met signaling pathway participating in the gefitinib resistance of different gene types of non-small cell lung cancer cells induced by HGF in vitro].

Authors - Xianglan Xuan
human

Yonsei Med J

Potential Antitumor Activity of SIM-89 in Non-Small Cell Lung Cancer Cells.

Authors - JunPei
rat

Mol Med Rep

Efficacy of intradiscal hepatocyte growth factor injection for the treatment of intervertebral disc degeneration.

Authors - FeiZou
mouse

Cell Tissue Res

Origin and hierarchy of basal lamina-forming and -non-forming myogenic cells in mouse skeletal muscle in relation to adhesive capacity and Pax7 expression in vitro.

Authors - TetsuroTamaki
human

J Appl Toxicol

Long-term maintenance of HepaRG cells in serum-free conditions and application in a repeated dose study.

Authors - SebastianKlein