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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human TGF beta 1

Activity

Typically ≤ 0.5 ng/mL EC50

Species Reactivity

human

Purity

>95%

Cat no : HZ-1011

Synonyms

CED, DPD1, LAP, TGF ?1, TGF beta 1, TGFB, TGFB1, TGFbeta



Technical Specifications

GeneID 7040
Species human
Expression HEK293
Activity Typically ≤ 0.5 ng/mL EC50
Purity >95%
Molecular Mass 25 kDa, homodimer, nonglycosylated
Formulation 50 mM NaOAc pH 4.5, See Certificate of Analysis for details
Species Reactivity human, mouse

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Product Description

Animal-free Recombinant Human TGF beta 1 is expressed from human 293 cells as a mature disulfide-linked homodimer with an apparent molecular mass of 25 kDa. Tests indicate that TGF beta 1 is as efficient at inducing IL-17 expression in Th17 cells, as cytokine purified from human platelets. This product is produced in a human cell expression system with serum-free, chemically defined media.

Background

TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, and cell differentiation. TGF acts synergistically with TGFA in inducing transformation process. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB having specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling being a potent stimulator of an osteoblastic bone formation (PMID: 11586292).

Synonyms

CED, DPD1, LAP, TGF ?1, TGF beta 1, TGFB, TGFB1, TGFbeta

Publications

SpeciesTitle
human

J Biol Chem

Transforming growth factor β (TGF-β)-induced up-regulation of TGF-β receptors at the cell surface amplifies the TGF-β response.

Authors - Dana Duan
human

PLoS Biol

Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis.

Authors - Lina Fu
human

Protein Cell

Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis.

Authors - Xing Zhang

Immunity

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.

Authors - Frédéric Van Gool
human

J Cell Biochem

microRNA-539 functions as a tumor suppressor in papillary thyroid carcinoma via the transforming growth factor β1/Smads signaling pathway by targeting secretory leukocyte protease inhibitor.

Authors - Cheng-Bi Xu
human

Cell Stem Cell

FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration.

Authors - Pengze Yan