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  • HEK293 expressed
  • Endotoxin-free
  • Animal-component free

Animal-free Recombinant Human TGF beta 2

Activity

Typically ≤ 0.5 ng/mL EC50

Species Reactivity

Human

Purity

>95%

Publications

4

Cat no : HZ-1092

Synonyms

Transforming Growth Factor-β2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin TGFbeta2, BSC1, BSC 1



Technical Specifications

GeneID 7042
Species Human
Expression HEK293
Activity Typically ≤ 0.5 ng/mL EC50
Purity >95%
Molecular Mass 25 kDa, homodimer, non-glycosylated
Formulation 50 mM NaOAc pH 4.5, See Certificate of Analysis for details
Species Reactivity human, mouse

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20oC) and (-80oC). Upon reconstitution we recommend that the solution can be stored at (4oC) for short term or at (-20oC) to (-80oC) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 20% ethanol + 50 mM NaOAc + 75 mM HOAc.

Product Description

Animal-free Recombinant Human TGF beta 2HuXp is expressed from human 293 cells as a mature disulfide-linked homodimer with apparent molecular mass of 25 kDa. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. The cytokine is greater than 95% pure.

Background

Transforming growth factor beta-2 (TGFB2) belongs to the TGF-beta family. TGFB2 is a secreted protein known as a cytokine that plays a vital role during embryonic development (PMID 19289080). TGFB2 regulates cell proliferation, differentiation, adhesion, migration by transducing the signal through transmembrane receptors type I and type II (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins (PMID 18313409). Disruption of the TGFB/SMAD pathway has been implicated in many cancers types. TGFB2 has suppressive effects on interleukin-2 dependent T-cell growth (PMID 12064833). The TGFβ2 protein plays a role in the blood vessels formation, the regulation of muscle tissue and body fat development. TGFβ-2 is especially abundant in tissues related to the skeleton, where it helps regulate bone growth and form the extracellular matrix in the spaces between cells.

Synonyms

Transforming Growth Factor-β2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin TGFbeta2, BSC1, BSC 1

Publications

SpeciesTitle
human

Invest Ophthalmol Vis Sci

Aldose Reductase Mediates Transforming Growth Factor β2 (TGF-β2)-Induced Migration and Epithelial-To-Mesenchymal Transition of Lens-Derived Epithelial Cells.

Authors - Kun-CheChang
human

Biol Reprod

Constitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and function.

Authors - YangGao
human

Biochem J

Soluble CD109 binds TGF-β and antagonizes TGF-β signalling and responses.

Authors - CarterLi
mouse,human

J Cell Mol Med

FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity.

Authors - EriKubo