Metabolic Adaptions of OXPHOS Organization and Function to Glycolytic Switch

Meet the expert: Dr Erika Fernández-Vizarra

The structural and functional organization of the mitochondrial respiratory chain (MRC) remains intensely debated. In this talk we will demonstrate the co-existence of two separate MRC organizations in human cells and postmitotic tissues. We show a link between the metabolic signatures converging at the pyruvate dehydrogenase complex and the structural and functional organization of the MRC, challenging the widespread notion of the MRC as a single functional unit and concluding that its structural heterogeneity warrants optimal adaptation to metabolic function.