APOL1 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66124-1-Ig |CloneNo.: 1G12D11

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Freight/Packing

Con: 236 μg/150 μl

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Species specificity:
human

Positive WB detected in:
human plasma tissue

Positive IP detected in:
human plasma tissue

Positive IHC detected in:
human liver tissue, human kidney tissue, human liver tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:20000-1:100000
IP : 0.5-4.0 ug for IP and 1:5000-1:50000 for WB
IHC : 1:50-1:1000
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
apolipoprotein L, 1

Calculated molecular weight:
44 kDa

Observed molecular weight:
39-45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
APOL1

Synonyms
APO L, APOL, APOL I, APOL1, Apolipoprotein L, Apolipoprotein L I, apolipoprotein L, 1, Apolipoprotein L1
Background

Human apolipo-protein L1 (APOL1) is a minor component of plasma high density lipoprotein (HDL) particles, acting as an interacting protein of apolipoprotein A1 (ApoA1). The human ApoL protein family was thought to be predominantly involved in lipid transport and metabolism. APOL1 is also involved in host innate immunity against Trypanosoma parasites. Once activated, APOL1 can lyse the parasite and protect human from infection. Genetic variants in APOL1 gene, which are found in African ancestry with high frequency, associate with chronic kidney disease, like focal segmental glomerulosclerosis (FSGS), HIV-associated nephropathy (HIVAN), and hypertensive nephropathy. APOL1 share structural and functional similarities with proteins of the Bcl-2 family and may has roles in apoptosis and autophagy. It is notable that APOL1 exists only in human and a few other primate species, and mouse does not express an APOL1 orthologue. This antibody recognizes the endogenous ApoL1 of 39-45 kDa in blood lysate.


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