Product Information
19783-1-AP targets AR in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
Peptide Predict reactive species |
| Full Name | androgen receptor |
| Calculated Molecular Weight | 99 kDa |
| GenBank Accession Number | NM_000044 |
| Gene Symbol | AR |
| Gene ID (NCBI) | 367 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P10275 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
AR, also named as DHTR and NR3C4, belongs to the nuclear hormone receptor family and NR3 subfamily. AR is a ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. AR is activated, but not phosphorylated, by HIPK3. Defects in AR are the cause of androgen insensitivity syndrome (AIS), previously known as testicular feminization syndrome (TFM), which is an X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Defects in AR are the cause of spinal and bulbar muscular atrophy X-linked type 1 (SMAX1) which also known as Kennedy disease. Defects in AR may play a role in metastatic prostate cancer. Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS) which also known as Reifenstein syndrome. This antibody is a rabbit polyclonal antibody raised against a peptide mapping within human AR.
Publications
What published studies show
The AR Polyclonal antibody (Cat# 19783-1-AP) has 3 total citations published in 2025 across three journals: Journal of Ethnopharmacology, Biochemical Pharmacology, and Scientific Reports. The associated research fields include obesity and brown fat thermogenesis, ovarian inflammation and apoptosis in PCOS, and diabetic seminal vesicle damage involving AQP8 expression. All studies utilized mouse or rat models with applications including WB, IHC, and IF.
| Species | Application | Title |
|---|---|---|
J Ethnopharmacol Flavonoid-rich extracts of Nelumbo nucifera leaves alleviate obesity in HFD-fed mice via microbiota-dependent modulation of brown fat thermogenesis | ||
Biochem Pharmacol Isatin ameliorates ovarian inflammation and apoptosis caused by hormonal imbalances in PCOS mice | ||
Sci Rep Curcumin administration alleviates seminal vesicle damage in type 1 diabetic rats by promoting AQP8 expression through AR activation |
