androgen receptor Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 22089-1-AP

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Freight/Packing

Con: 73 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
PC-3 cells, HepG2 cells, LNCaP cells, MCF-7 cells, mouse heart tissue, NIH/3T3 cells

Positive IHC detected in:
human prostate cancer tissue, human prostate cancer tissue, mouse ovary tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
androgen receptor

Calculated molecular weight:
914aa,99 kDa

Observed molecular weight:
75-80 kDa,100-110 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
AR

Synonyms
AIS, androgen receptor, AR, DHTR, Dihydrotestosterone receptor, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
Background

AR, also named as DHTR and NR3C4, belongs to the nuclear hormone receptor family and NR3 subfamily. AR is a ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. AR is activated, but not phosphorylated, by HIPK3. Defects in AR are the cause of androgen insensitivity syndrome (AIS), previously known as testicular feminization syndrome (TFM), which is an X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Defects in AR are the cause of spinal and bulbar muscular atrophy X-linked type 1 (SMAX1) which also known as Kennedy disease. Defects in AR may play a role in metastatic prostate cancer. Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS) which also known as Reifenstein syndrome. This antibody is a rabbit polyclonal antibody raised against residues near the N terminus of human AR. AR exists various isoforms with MV 110 kDa and 75-80 kDa. (PMID: 19244107 )


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