ATF2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 11908-1-AP

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Freight/Packing

Con: 52 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, mouse brain tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
activating transcription factor 2

Calculated molecular weight:
209aa,23 kDa

Observed molecular weight:
60 kDa,64 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ATF2

Synonyms
ATF2, CRE BP1, CREB 2, CREB2, CREBP1, HB16, TREB7
Background

ATF2, also named as CREB2 and CREBP1, contains one bZIP domain and one C2H2-type zinc finger. It belongs to the bZIP family. ATF2 binds to the cAMP-responsive element(CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. It is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. ATF2 binds DNA as a dimer and can form a homodimer in the absence of DNA. It binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity. This antibody can recognize all the isoforms of human ATF2.


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