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ATF2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 11908-1-AP

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Tested Applications
Applications:
ELISA, WB, IF
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11908-1-AP;HeLa cells

HeLa cells were subjected to SDS PAGE followed by western blot with 11908-1-AP(ATF2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours

11908-1-AP;HeLa cells

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HeLa cells using 11908-1-AP(ATF2 antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Species specificity:
human, mouse, rat
Positive WB detected in:
HeLa cells, mouse brain tissue
Positive IF detected in:
HeLa cells
Recommended dilution:
WB : 1:500-1:1000
IF : 1:50-1:500

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
ATF2 fusion protein ag2581
Full name:
activating transcription factor 2
Calculated molecular weight:
209aa,23 kDa
Observed molecular weight:
60 kDa,64 kDa
GenBank accession number:
BC026175
Gene ID (NCBI):
1386
Gene symbol
ATF2
Synonyms
ATF2, CRE BP1, CREB 2, CREB2, CREBP1, HB16, TREB7
Background

ATF2, also named as CREB2 and CREBP1, contains one bZIP domain and one C2H2-type zinc finger. It belongs to the bZIP family. ATF2 binds to the cAMP-responsive element(CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. It is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. ATF2 binds DNA as a dimer and can form a homodimer in the absence of DNA. It binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity. This antibody can recognize all the isoforms of human ATF2.


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