ATF4 Antibody 3 Publications

Mouse Monoclonal| Catalog number: 60035-1-Ig |CloneNo.: 3E4C5

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Freight/Packing

Con: 180 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HepG2 cells, HEK-293 cells, human placenta tissue

Positive IHC detected in:
human breast cancer tissue, human pancreas tissue, human pancreas cancer tissue, human small intestine tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:1000-1:4000
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
activating transcription factor 4 (tax-responsive enhancer element B67)

Calculated molecular weight:
39 kDa

Observed molecular weight:
45-50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ATF4

Synonyms
ATF4, CREB 2, CREB2, DNA binding protein TAXREB67, TAXREB67, TXREB
Background

ATF4 is a transcription factor, that accumulates predominantly in osteoblasts, where it regulates terminal osteoblast differentiation and bone formation. As a basic leucine-zipper (bZip) transcription factor, ATF4 can regulate amino acid metabolism, cellular redox state, and anti-stress responses. It also regulates age-related and diet-induced obesity and glucose homeostasis in mammals, and has conserved metabolic functions in flies. Due to its location at chromosome 22q13, a region linked to schizophrenia, ATF4 is considered as a positional candidate gene for schizophrenia. Otherwise, since ATF4 is induced by tumour microenvironmental factors, and regulates processes relevant to cancer progression, it might serve as a potential therapeutic target in cancer. This antibody is a mouse monoclonal antibody raised against full length human ATF4 antigen. The antibody recognizes the 38kd ATF4 protein and its phosphorylated forms (50kd).


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