CBLB Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66353-1-Ig |CloneNo.: 2D3A2

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, mouse, pig, rat

Positive WB detected in:
RAW 264.7 cells, rat heart tissue

Positive IHC detected in:
human heart tissue, human heart tissue, human testis tissue

Positive IF detected in:
RAW 264.7 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:100-1:400
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG3

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Cas-Br-M (murine) ecotropic retroviral transforming sequence b

Calculated molecular weight:
982aa,109 kDa

Observed molecular weight:
110 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CBLB

Synonyms
CBLB, DKFZp686J10223, DKFZp779A0729, DKFZp779F1443, FLJ36865, FLJ41152, Nbla00127, RING finger protein 56, RNF56, SH3 binding protein CBL B
Background

CBLB(E3 ubiquitin-protein ligase CBL-B) is also known as RNF56 and plays a necessary role to prevent the inappropriate activation of NF-B in response to lipopolysaccharide and to polymicrobial sepsis. CBLB can be phosphorylated on tyrosine and serine residues upon TCR or BCR activation, and upon various types of cell stimulation.. It also has a crucial role in the prevention of chronic inflammation and autoimmunity. This protein has 3 isoforms produced by alternative splicing.


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