CD63 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 25682-1-AP

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Freight/Packing

Con: 39 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Transfected HEK-293 cells

Positive IHC detected in:
human malignant melanoma tissue, human tonsillitis tissue, human lymphoma tissue, mouse pancreas tissue

Positive IF detected in:
A431 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CD63 molecule

Calculated molecular weight:
26 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CD63

Synonyms
CD63, CD63 antigen, CD63 molecule, Granulophysin, LAMP 3, ME491, MLA1, OMA81H, Tetraspanin 30, Tspan 30, TSPAN30
Background

CD63, known as LAMP-3, is a lysosomal membrane protein that belongs to the tetraspanin family. This protein plays many important roles in immuno-physiological functions. It mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD63 is expressed on activated platelets, thus it may function as a blood platelet activation marker. CD63 is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation. The CD63 tetraspanin is highly expressed in the early stages of melanoma and decreases in advanced lesions, suggesting it as a possible suppressor of tumor progression. Deficiency of this protein is associated with Hermansky-Pudlak syndrome.


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