CDC25C Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 16485-1-AP

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human

Positive WB detected in:
K-562 cells, HepG2 cells, Raji cells

Positive IP detected in:
K-562 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cell division cycle 25 homolog C (S. pombe)

Calculated molecular weight:
473aa,53 kDa

Observed molecular weight:
53 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CDC25C

Synonyms
CDC25, CDC25C, M phase inducer phosphatase 3
Background

The cell division cycle 25 (CDC25) family of proteins are highly conserved dual specificity phosphatases that activate cyclin-dependent kinase (CDK) complexes, which in turn regulate progression through the cell division cycle. CDC25C(cell division cycle 25 homolog C) is one of the 3 isoforms of CDC25 in mammalian cells. It is present in the cytoplasm of asynchronously growing human cells(PMID:10330186). And it may be phosphorylated by its own substrate, an active cdc2-cyclin B complex, to create an autoactivation loop(PMID:7937793). It can be hyperphosphorylated to get the active form of 70 kDa(PMID:18296513).


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