Complement factor H Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 12748-1-AP

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Freight/Packing

Con: 53 μg/150 μl

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Species specificity:
human

Positive WB detected in:
human blood tissue

Positive IP detected in:
human plasma tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
complement factor H

Calculated molecular weight:
1231aa,139 kDa

Observed molecular weight:
150 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CFH

Synonyms
ARMD4, ARMS1, CFH, CFHL3, Complement factor H, Factor H, FH, FHL1, H factor 1, HF, HF1, HF2, HUS
Background

Complement factor H (CFH) is an abundant plasma glycoprotein that regulates the function of the alternative complement pathway in fluid phase and on cellular surfaces (PMID: 2963625). Factor H binds to C3b, accelerates the decay of the alternative pathway C3-convertase (C3bBb) and acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b (PMID: 15163532). It plays a critical role in the homeostasis of the complement system in plasma and in the protection of bystander host cells and tissues from damage by complement activation. Abnormalities in factor H have been associated with renal disease (PMID: 18190458).


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