CNOT1 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66507-1-Ig |CloneNo.: 1A10A11

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Con: 150 μg/150 μl

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Species specificity:
Human

Positive WB detected in:
human cerebellum tissue, mouse kidney tissue, HEK-293 cells, pig kidney tissue

Positive IHC detected in:
human heart tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CCR4-NOT transcription complex, subunit 1

Calculated molecular weight:
267 kDa

Observed molecular weight:
240-250 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CNOT1

Synonyms
AD 005, CCR4 associated factor 1, CDC39, CNOT1, DKFZp686E0722, DKFZp686O168, FLJ36492, FLJ90644, hNOT1, KIAA1007, NOT1, NOT1H
Background

CNOT1 is a component of CCR4-NOT protein complex, which is a regulator of RNA polymerase II transcription, acts as a transcription repressor. CCR4-NOT complex could participate in transcription as well as mRNA degradation. It's highly expressed in brain, heart, thymus, but weak in skeletal muscle and colon. CNOT1 undergoes alternative splicing to produce four isoforms.This is a rabbit polyclonal antibody raised against part chain of C-terminal CNOT1 of human origin. CNOT1 exsits as many isoforms. The isoform one is about 267 kDa and the isoform four is about 173 kDa.


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