Connexin-26 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 51037-2-AP

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Con: 90 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue

Positive IHC detected in:
human colon cancer tissue

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
gap junction protein, beta 2, 26kDa

Calculated molecular weight:
26 kDa

Observed molecular weight:
26 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GJB2

Synonyms
Connexin 26, Connexin-26, CX26, DFNA3, DFNA3A, DFNB1, DFNB1A, Gap junction beta 2 protein, GJB2, HID, KID, NSRD1, PPK
Background

The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Connexin-26 (GJB2) is a beta class gap junction protein. Mutations in the gene for connexin-26 are responsible for as much as 50% of pre-lingual, recessive deafness.


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