DGCR8 Antibody 3 Publications

Mouse Monoclonal| Catalog number: 60084-1-Ig |CloneNo.: 4D11A3

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Con: 150 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
K562 cells, HepG2 cells, BxPC-3 cells, human brain tissue, HEK-293 cells, RAW 264.7 cells, A431 cells

Positive IP detected in:
K-562 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
DiGeorge syndrome critical region gene 8

Calculated molecular weight:
773aa,86 kDa

Observed molecular weight:
120 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DGCR8

Synonyms
C22orf12, DGCR8, DGCRK6, Gy1
Background

DGCR8 is a RNA-binding protein that assists the Rnase III enzyme Drosha in the processing of microRNAs (miRNAs), which regulate the expression of a large number of protein-coding genes[PMID: 22580560]. DGCR8, which contains two double-stranded RNA (dsRNA)-binding domains, may be an essential component of the primary miRNAs processing complex, along with Drosha, promoting the processing of primary microRNA to precursor microRNA. It is ubiquitous expressed in human and mouse tissues, and is deleted in DiGeorge syndrome[22323604]. The calculated molecular weight of DGCR8 is 82-86 kDa, but the post-modified DGCR8 is about 120 kDa.


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