DIABLO Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 10434-1-AP

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Freight/Packing

Con: 22 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HepG2 cells, HEK-293 cells, HeLa cells, HepG2 cells, Jurkat cells, mouse testis tissue, Sp2/0 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human testis tissue, human kidney tissue, human testis tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
diablo homolog (Drosophila)

Calculated molecular weight:
27 kDa

Observed molecular weight:
20 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DIABLO

Synonyms
DIABLO, diablo homolog (Drosophila), Diablo homolog, mitochondrial, DIABLO S, FLJ10537, FLJ25049, SMAC, SMAC3
Background

DIABLO, also named as SMAC, promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. This antibody recognizes all the three isoforms (27 kDa and 22 kDa) of DIABLO. The highest expression was in the testis, adrenal gland, and ears.


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