GAC-specific Antibody 8 Publications

Rabbit Polyclonal| Catalog number: 19958-1-AP

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Con: 43 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HEK-293 cells, HEK-293 cells, mouse kidney tissue

Positive IP detected in:
mouse kidney tissue

Positive IHC detected in:
human heart tissue, human heart tissue, human kidney tissue, human pancreas cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
glutaminase

Calculated molecular weight:
65 kDa

Observed molecular weight:
60-65 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
GLS

Synonyms
AAD20, DKFZp686O15119, FLJ10358, GAC, GAC-specific, GLS, GLS1, glutaminase C, K glutaminase, KIAA0838, L glutamine amidohydrolase
Background

Glutaminase C (GAC), a splicing variant of the kidney-type glutaminase (KGA) gene, is a vital mitochondrial enzyme protein that catalyzes glutamine to glutamate. GAC is the only isoform present in the mitochondria (PMID:22228304). In a normal state, immunodecorationwith antibodies directed against GAC identified an abundant complex of 232 kDa as a tetrameric form of GAC, the DPAA can directly destructed the native tetrameric GAC complex to accumulate the unassembled one (50-90 kDa). (PMID:22493432). This antibody is specific to GAC isoform. It has no cross reaction to KGA.


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