Validation Data Gallery
|Sample-dependent, check data in validation data gallery|
13747-1-AP targets GADD45A in WB, IHC,ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||GADD45A fusion protein Ag4687|
|Full Name||growth arrest and DNA-damage-inducible, alpha|
|Calculated molecular weight||165 aa, 18 kDa|
|GenBank accession number||BC011757|
|Gene ID (NCBI)||1647|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
GADD45A, also named as DDIT1 and GADD45, belongs to the GADD45 family. It binds to proliferating cell nuclear antigen. GADD45A may affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. GADD45A plays an essential role in active DNA demethylation during terminal osteogenic differentiation of adipose-derived mesenchymal stem cells. GADD45A has Dimer (~36 kDa) and Mono (~18 kDa) forms (PMID:11498536).
Selective activation of tumor-suppressive MAPKP signaling pathway by triptonide effectively inhibits pancreatic cancer cell tumorigenicity and tumor growth.
Bosn J Basic Med Sci
CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.
Int J Nanomedicine
TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats.
Neural Regen Res
Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion.
Overexpression of HP1γ is associated with poor prognosis in non-small cell lung cancer cell through promoting cell survival.
Onco Targets Ther
GADD45a Mediated Cell Cycle Inhibition Is Regulated By P53 In Bladder Cancer.