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GADD45A Polyclonal antibody

GADD45A Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, ELISA

Conjugate

Unconjugated

Cat no : 13747-1-AP

Synonyms

DDIT 1, DDIT1, GADD45, GADD45A



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Product Information

13747-1-AP targets GADD45A in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen GADD45A fusion protein Ag4687
Full Name growth arrest and DNA-damage-inducible, alpha
Calculated molecular weight 165 aa, 18 kDa
GenBank accession numberBC011757
Gene symbol GADD45A
Gene ID (NCBI) 1647
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

GADD45A, also named as DDIT1 and GADD45, belongs to the GADD45 family. It binds to proliferating cell nuclear antigen. GADD45A may affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. GADD45A plays an essential role in active DNA demethylation during terminal osteogenic differentiation of adipose-derived mesenchymal stem cells. GADD45A has Dimer (~36 kDa) and Mono (~18 kDa) forms (PMID:11498536).

Publications

SpeciesApplicationTitle
humanWB

Biochem Pharmacol

Selective activation of tumor-suppressive MAPKP signaling pathway by triptonide effectively inhibits pancreatic cancer cell tumorigenicity and tumor growth.

Authors - Bin Zhang
mouseWB

Bosn J Basic Med Sci

CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.

Authors - Yanjie Wang
ratWB

Int J Nanomedicine

TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats.

Authors - Bin Han
ratWB

Neural Regen Res

Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion.

Authors - Guo-Qian He
humanWB

Tumour Biol

Overexpression of HP1γ is associated with poor prognosis in non-small cell lung cancer cell through promoting cell survival.

Authors - Ji Zhou
humanWB

Onco Targets Ther

GADD45a Mediated Cell Cycle Inhibition Is Regulated By P53 In Bladder Cancer.

Authors - Na Han