TIM3 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 11872-1-AP

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 21 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse

Positive WB detected in:
Raji cells, Daudi cells, PC-3 cells, RAW 264.7 cells

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
hepatitis A virus cellular receptor 2

Calculated molecular weight:
301aa,33 kDa

Observed molecular weight:
33 kDa, 52 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HAVCR2

Synonyms
CD366, FLJ14428, HAVcr 2, HAVCR2, KIM 3, T cell membrane protein 3, Tim 3, TIM3, TIM-3, TIMD 3, TIMD3
Background

TIM3, also known as HAVCR2, is a member of the recently discovered T cell Ig and mucin domain-containing molecule superfamily. TIM3 is a negative regulatory molecule that is important for T cell tolerance and has a crucial role in autoimmunity and T cell exhaustion during chronic viral infection (PMID: 23180819). TIM3 is expressed by T-helper type 1 (Th1) cells, macrophage, monocyte, dendritic cells, CD8+ T cell and other lymphocyte subsets. Galectin-9 is a ligand for TIM3. TIM3-galectin-9 pathway negatively regulates T helper type 1 immunity (PMID: 16286920). TIM3 is a 280-aa membrane protein with a calculated molecular weight of 33 kDa, the higher molecular weights between 50 and 70 kDa probably represent glycosylated TIM3 (PMID: 20107545; 17069754; 11725301)


Back
to top