GRP75 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 14887-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
NIH/3T3 cells, A549 cells

Positive IP detected in:
mouse brain tissue, NIH/3T3 cells

Positive IHC detected in:
human breast cancer tissue, human brain tissue, human breast cancer tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:1000-1:4000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
heat shock 70kDa protein 9 (mortalin)

Calculated molecular weight:
74 kDa

Observed molecular weight:
74-75 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HSPA9

Synonyms
CSA, GRP 75, GRP75, Heat shock 70 kDa protein 9, HSPA9, HSPA9B, Mortalin, MOT, mot 2, MOT2, MTHSP75, PBP74, Peptide binding protein 74
Background

GRP75 (also known as mortalin, HSPA9 or mt-Hsp70) is a constitutively expressed member of the HSPA (HSP70) family of heat-shock proteins. It is located in the mitochondrial matrix and anti-GRP75 is commonly used as the marker for mitochondria. It has been reported that GRP75 is enriched in cancer cells and contributes to carcinogenesis. In addition, decreased expression level of GRP75 has been found in neurodegenerative disorders like Parkinson’s disease. This antibody recognized the endogenous HSPA9 protein in NIH/3T3 cells. (21640711, 22920904)


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