LDHA Antibody 0 Publications

Mouse Monoclonal| Catalog number: 66287-1-Ig |CloneNo.: 2E2G6

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Freight/Packing

Con: 225 μg/150 μl

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Species specificity:
human, mouse, pig

Positive WB detected in:
pig liver tissue

Positive IHC detected in:
human liver cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:3000
IHC : 1:100-1:400
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
lactate dehydrogenase A

Calculated molecular weight:
332aa,37 kDa

Observed molecular weight:
28 kDa, 40 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
LDHA

Synonyms
lactate dehydrogenase A, LDH A, LDH M, LDH muscle subunit, LDH1, LDHA, PIG19
Background

LDHA, also named as LDH-M and NY-REN-59, is an enzyme which catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD+. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumours, and belongs to the lactate dehydrogenase family. It has long been known that many human cancers have higher LDHA levels compared to normal tissues. It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional myoglobinuria. LDHA has some isoforms with MW 26-40 kDa.


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