TIP47 Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 10694-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HeLa cells, HEK-293 cells, Jurkat cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
mouse liver tissue, mouse ovary tissue

Positive IF detected in:
MEF cells, oleic acid treated HeLa cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
mannose-6-phosphate receptor binding protein 1

Calculated molecular weight:
47 kDa

Observed molecular weight:
47 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
M6PRBP1

Synonyms
M6PRBP1, Perilipin 3, Placental protein 17, PLIN3, TIP47
Background

Mannose 6-phosphate receptors (M6PRs) transport newly synthesized lysosomal hydrolases from the Golgi to prelysosomes and then return to the Golgi for another round of transport. M6PRBP1 (mannose-6-phosphate receptor binding protein 1), also known as TIP47, PLIN3 or PP17, interacts with the cytoplasmic domains of both cation-independent and cation-dependent M6PRs, and is required for endosome-to-Golgi transport. In addition to M6PR recycling, M6PRBP1 plays a role in lipid droplet biogenesis, and is also implicated in rhodopsin photobleaching and viral infection. M6PRBP1 has been found to be expressed in a variety of human tissues (including colon, liver and lung parenchyme, mammary gland, and skin) and is overexpressed in certain cancer cell lines. It binds to lipid droplets and also occurs in cytosol and on endosomal membranes.


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