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MDM2 belongs to the MDM2/MDM4 family. It inhibits TP53/p53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. MDM2 can bind to the p53 tumor suppressor protein and negatively regulate its functions in transcription, cell cycle arrest, and apoptosis. Human mdm2 has a calculated molecular mass of 54 kDa.