MECP2 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 10861-1-AP

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Freight/Packing

Con: 27 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat

Positive WB detected in:
MDA-MB-453s cells, human brain tissue, mouse heart tissue, mouse lung tissue, mouse ovary tissue, SH-SY5Y cells

Positive IP detected in:
MCF-7 cells

Positive IHC detected in:
human prostate cancer tissue, human brain tissue

Positive IF detected in:
HepG2 cells

Positive FC detected in:
NIH/3T3 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
methyl CpG binding protein 2 (Rett syndrome)

Calculated molecular weight:
52 kDa,53 kDa

Observed molecular weight:
75 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MECP2

Synonyms
AUTSX3, DKFZp686A24160, MeCp 2 protein, MECP2, Methyl CpG binding protein 2, MRX16, MRX79, MRXS13, MRXSL, PPMX, RTS, RTT
Background

METHYL-CpG-BINDING PROTEIN 2(MECP2), is a chromatin-associated protein that can both activate and repress transcription. Mecp2 in the adult mouse is high in the brain, lung, and spleen, lower in heart and kidney. MECP2 takes part in the control of neuronal activity-dependent gene regulation, and this process may underlie the pathology of Rett syndrome, a severe developmental disorder with autistic phenotypes. As compared to wild-type monkeys, MECP2 transgenic monkeys exhibited a higher frequency of repetitive circular locomotion and increased stress responses, as measured by the threat-related anxiety and defensive test. Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Two isoforms of MECP2 exist due to alternative splicing events.This antibody reacts with the MECP2 and phosphorylated MECP2 proteins.


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