MICAL1 Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 14818-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
Jurkat cells,mouse lung tissue, human brain tissue, HeLa cells, HEK-293 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human lung tissue, human heart tissue, human lung tissue, human ovary tissue, human placenta tissue, human skin tissue, human spleen tissue, human testis tissue

Positive IF detected in:
HeLa

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
microtubule associated monoxygenase, calponin and LIM domain containing 1

Calculated molecular weight:
118 kDa

Observed molecular weight:
120 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
MICAL1

Synonyms
DKFZp434B1517, FLJ11937, FLJ21739, MICAL, MICAL 1, MICAL1, NICAL
Background

MICALs (Molecules Interacting with CasL) are atypical multidomain flavoenzymes with diverse cellular functions.There are three known isoforms, MICAL1, MICAL2 and MICAL3, as well as the MICAL-like proteins MICAL-L1 and MICAL-L2. MICAL1 has four conserved domains: an N-terminal flavin adenine dinucleotide (FAD) binding domain, a calponin homology (CH) domain, a Lin11, Isl-1 and Mec-3 (LIM) domain and a C-terminal coiled-coil (CC) domain. MICAL1 is reported to regulate actin stress fibers and be required for normal actin organization. It may also be involved in apoptosis through binding with NDR (nuclear Dbf2-related) kinases. This antibody specially recognizes MICAL1.


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