NCAM1/CD56 Antibody 7 Publications

Rabbit Polyclonal| Catalog number: 14255-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 41 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue,mouse cerebellum tissue, rat brain tissue

Positive IHC detected in:
human colon tissue,human spleen tissue, mouse brain tissue, human gliomas tissue, human lung cancer tissue

Positive FC detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:1000-1:4000
IHC : 1:200-1:800

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
neural cell adhesion molecule 1

Calculated molecular weight:
95 kDa

Observed molecular weight:
120 kDa, 140 kDa, 180 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NCAM1

Synonyms
CD56, MSK39, N CAM 1, NCAM, NCAM 1, NCAM1
Background

Neural cell adhesion molecule 1 (NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin (Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurones, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA (PMID: 9696812). The glycosylphosphatidylinositol (GPI)-anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronection-type III repeats (FNIII). All three forms can be posttranslationally modified by addition of polysialic acid (PSA) (PMID: 14976519). Several other isofroms have also been described (PMID: 1856291).


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