TTF1; NKX2-1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 21777-1-AP

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Freight/Packing

Con: 47 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HeLa cells, A549 cells, HeLa cells

Positive IHC detected in:
human lung cancer tissue, human liver cancer tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
NK2 homeobox 1

Calculated molecular weight:
42 kDa

Observed molecular weight:
41-45 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
NKX2-1

Synonyms
BHC, Homeobox protein Nkx 2.1, NK 2, NK2 homeobox 1, NKX2 1, NKX2.1, NKX2-1, NKX2A, TEBP, Thyroid nuclear factor 1, Thyroid transcription factor 1, TITF1, TTF 1, TTF1
Background

NKX2-1, also named as NKX2A, TITF1 and TTF1, belongs to the NK-2 homeobox family. It is a transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. NKX2-1 is crucial in the maintenance of the thyroid differentiation phenotype. It may play a role in lung development and surfactant homeostasis. Defects in NKX2-1 are the cause of benign hereditary chorea (BHC), choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD). The antibody is specific to NKX2-1.


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